Which tests are known to be seriously affected by hemolysis?

Hemolysis, the breakdown of red blood cells, can significantly impact various laboratory test results by releasing intracellular components into the plasma. Among the tests listed, aspartate aminotransferase (AST), potassium, and lactate dehydrogenase (LDH) are particularly sensitive to the effects of hemolysis.

When red blood cells lyse, AST and LDH are released into the serum, leading to elevated levels that may not accurately reflect the patient's actual biochemical status. Additionally, potassium is also released from inside the red blood cells, which can result in spuriously high potassium levels if hemolysis occurs. This can lead to incorrect interpretations of the patient’s health, especially in critical situations where accurate potassium levels are vital for cardiac function.

In contrast, other tests might not be as heavily impacted by hemolysis. For example, cholesterol and glucose can be less affected, as they are not primarily derived from red blood cells. Blood cell counts are more related to cell morphology and may be measured using separate methods that are less sensitive to hemolysis. Prothrombin time, while important, is typically more stable compared to the specific analytes affected by hemolysis listed in the correct choice. Thus, the biochemical